The Elimination of Bromides from the Blood Stream*

Two dogs, weighing 15 and 20 kilos respectively, were employed for the experiments. Bromide in blood and urine was determined by the method of Behr, Palmer, and Clarke (1) ; total halide was estimated in aliquot portions of the alkaline ash solutions by the Harvey modification of the Volhard procedure (2). Carbon dioxide was estimated in serum (collected under oil) by the procedure of Van Slyke and Neil1 (3), with the closed manometer apparatus. Total fixed base determinations were made by the procedure of Stadie and Ross (4). Urine was collected without catheterization. The salt-poor diet upon which the dogs were kept consisted of ground dog biscuit with the addition of a 1 per cent solution of extract of beef and 2.5 cc. of cod liver oil daily for each dog. Tap water was allowed ad libitum. On this diet the dogs received